New potent sialyltransferase inhibitors
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Authors
Boltje, T.J.
Heise, T. Torben
Pijnenborg, J.F.A. Johan
Büll, C. Christian
Adema, G.J. Gosse
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Abstract
The present invention relates to anew class of sialyltransferase inhibitors. The class features a carbamate or similar moiety on the amine of a neuraminic acid derivative. Such inhibitors are suitable for use as a medicament, for example for treating, preventing, or delaying bacterial infection, viral infection, cancer, a disorder of sialic acid metabolism, or an autoimmune disease.
