Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia
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Bekkering, S. Siroon
Stiekema, L.C.A.
Moens, S. Bernelot
Verweij, S.L.
Novakovic, Boris
Prange, K.
Versloot, M.
Lennep, J.E.Roeters van
Stunnenberg, H.G. Hendrik
Winther, M. de
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Abstract
Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.