Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
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Es, M.A. van
Vught, P.W. van
Blauw, H.M.
Franke, L.
Saris, C.G.J. Christiaan
Bosch, L.
Jong, S.W. de
Jong, V. de
Baas, F.
Slot, R. van 't
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Abstract
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.