Organisation modelling for the dynamics of complex biological processes

Abstract

This paper shows how an organisation modelling approach can be used to model the dynamics of biological organisation, in particular the circulatory system in biological organisms (mammals). This system consists of a number of components that are connected and grouped together. Dynamic properties at different levels of aggregation of this organisation model have been identified, and interlevel relationships between these dynamic properties at different aggregation levels were made explicit. Based on the executable properties simulation has been performed and properties have been checked for the produced simulation traces. Thus the logical relationships between properties at different aggregation levels have been verified. Moreover, relationships between roles within the organisation model and realisers of these roles have been defined. This case study shows that within biological and medical domains organisation modelling techniques can play a useful role in modelling complex systems at a high level of abstraction.