Pharmacokinetics of zidovudine dosed twice daily according to World Health Organization weight bands in Ugandan HIV-infected children
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Fillekes, Q. Quirine
Kendall, L.
Kitaka, S.
Mugyenyi, P.
Musoke, P.
Ndigendawani, M.
Bwakura-Dangarembizi, M.
Gibb, D.M.
Burger, D.M. David
Walker, A.S.
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Abstract
Data on zidovudine pharmacokinetics in children dosed using World Health Organization weight bands are limited. About 45 HIV-infected, Ugandan children, 3.4 (2.6-6.2) years, had intensive pharmacokinetic sampling. Geometric mean zidovudine AUC0-12h was 3.0 h.mg/L, which is higher than previously observed in adults, and was independently higher in those receiving higher doses, younger and underweight children. Higher exposure was also marginally associated with lower hemoglobin.