Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists.
Loading...
Date
Authors
Storelli, S.
Verdijk, P. Pauline
Verzijl, D.
Timmerman, H. Hans
Stolpe, A. Anja
Tensen, C.P.
Smit, M.J.
Esch, I.J. de
Leurs, R.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
A series of 3-phenyl-3H-quinazolin-4-ones have been synthesized and tested for affinity and activity at the chemokine CXCR3 receptor. The most potent compound (1d) has been evaluated using radioligand binding and calcium mobilization assays and is considered a useful tool for further characterization of the CXCR3 receptor.