Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients
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Authors
Lavergne, R.A.
Chouaki, T.
Hagen, F.
Toublanc, B.
Dupont, H.
Jounieaux, V.
Meis, J.F.G.M. Jacques
Morio, F.
Pape, P. Le
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Abstract
A case of fatal aspergillosis due to a TR46/Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis.