New biomarkers for early detection of cardiotoxicity after treatment with docetaxel, doxorubicin and cyclophosphamide
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Boxtel, W. Wim
Bulten, B.F. Ben
Mavinkurve-Groothuis, A.M.C. Annelies
Bellersen, L. Louise
Mandigers, C.M.
Joosten, L.A.B. Leo
Kapusta, L. Livia
Geus-Oei, L.F. Lioe-Fee
Laarhoven, H.W.M. Hanneke
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Abstract
OBJECTIVE: Assessing a diverse biomarker panel (NT-proBNP, TNF-alpha, galectin-3, IL-6, Troponin I, ST2 and sFlt-1) to detect subclinical cardiotoxicity after treatment with anthracyclines. METHODS: Of 55 breast cancer patients biomarkers were assessed and echocardiography was performed one year after treatment with anthracyclines. RESULTS: 29.1% of patients showed abnormal biomarker levels: NT-proBNP in 18.2%, TNF-alpha and Galectin-3 in 7.3%. IL-6, troponin I, ST2 and sFlt-1 were normal in all patients. A correlation between left ventricular ejection fraction (LVEF) and NT-proBNP was observed (r = -0.564, p </= 0.01). CONCLUSION: The evaluated biomarkers do not contribute to early detection. Future research should focus on NT-proBNP.